Category Archives: Technology

Productivity in Upstream Processes

By Ken Clapp, Upstream Product Manager, GE Healthcare Although keeping a better-faster-cheaper mindset, the bioprocessing industry cannot sacrifice quality. Over the past few decades, tremendous improvements have been made, including the industrialization of Chinese hamster ovary (CHO) cells and biologics … Continue reading

Posted in Education, Engineering, INTERPHEX, Operations, Packaging, Pharmaceuticals, Processes, Production, Technology, Upstream | Tagged , , , , , , , , , , | Leave a comment

Designing for Operational Excellence

Kristina Pumphrey, PE – CRB Associate / Operational Improvement Specialist It seems counterintuitive to wait until a facility is in operation to apply Lean/ Six Sigma techniques to improve operational efficiency.  There are many decisions made during design that affect … Continue reading

Posted in Education, Engineering, INTERPHEX, Operations, Packaging, Pharmaceuticals, Production, Technology | Tagged , , , , , , , , | Leave a comment

Maximizing On-Target Yields during The Production of APIs

Maximizing on-target yields during the production of active pharmaceutical ingredients (APIs) is a crucial goal for efficient pharmaceutical manufacturing.  Meeting that goal can have a significant impact on your bottom line.  On-target optimization depends on achieving the tightest particle size … Continue reading

Posted in Education, Engineering, INTERPHEX, Pharmaceuticals, Technology, Uncategorized | Tagged , , , , , | Leave a comment

The Transformation of the Industry

Since 1974, the year when it was founded, Marchesini Group has grown progressively through acquisitions and partnerships with complementary companies.  Today, the Group is capable of supplying complete lines to handle the entire production process from dispensing product in vials, … Continue reading

Posted in Engineering, INTERPHEX, Pharmaceuticals, Production, Supply Chain, Technology, Uncategorized | Tagged , , , , , | Leave a comment

Enhanced Wet Milling Technology for API Size Reduction

Active pharmaceutical ingredient (API) milling is a key step in many drug development processes. Traditional dry milling technologies (i.e. media mills, pin mills) used for this application have come under increased scrutiny due to yield losses, hygiene concerns, process train … Continue reading

Posted in Engineering, INTERPHEX, Pharmaceuticals, Technology, Uncategorized | Tagged , , , , | 1 Comment

Production of Polymer Nanoparticles Using a Microfluidizer

Over the last decade, biodegradable polymers have been of increasing interest due to their many benefits.  These benefits include the ability to deliver a combination of varying therapeutic ingredients, the capability to include targeting moieties, and to protect APIs from … Continue reading

Posted in Engineering, INTERPHEX, Nanoparticles, Pharmaceuticals, Polymer, Production, Supply Chain, Technology, Uncategorized | Tagged , , , , , | Leave a comment

Modern Press Technology

Tablet press technology is evolving as rapidly as the speeds at which the presses themselves are capable of running. While the old, industry assertion that “all presses make tablets in the same fashion” does have a kernel of truth to … Continue reading

Posted in Engineering, INTERPHEX, Pharmaceuticals, Press, Technology | Tagged , , , , , , | Leave a comment