Maximizing on-target yields during the production of active pharmaceutical ingredients (APIs) is a crucial goal for efficient pharmaceutical manufacturing. Meeting that goal can have a significant impact on your bottom line. On-target optimization depends on achieving the tightest particle size distributions (PSDs) possible. Of course, consistently achieving uniform particle size is important for any number of applications. Yet when it comes to APIs, it can mean the difference between success and failure.
The PSD of a given API influences numerous aspects of final drug performance, including dissolution, bioavailability, stability, etc. These tightly controlled characteristics also affect product manufacturability, by influencing everything from blend uniformity of APIs and excipients, to parameters such as flow, compactability, etc.
Tight PSDs are clearly crucial, and achieving them can spell the difference between profit and loss. Many pharmaceutical ingredient manufacturers have learned to rely on Quadro® Comil® technology for proven, impressive results.
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