How to Achieve Controlled Release & Accurate Dosing and Numerous Combinations in Capsules

Courtesy of ACG North America Solid Dosage Consumables and Machinery

Efficiency in release profiles of drug delivery systems has been a cause of great concern to pharmacists due to undesirable toxicity, unpredictable absorption and repetitive dosing. The primary challenge is not just controlled release, but also ease of preparation, economy, accurate dosing and better patient compliance.

Increased effectiveness of the drug and reduction of dosing frequency are achievable by a plurality of matrix dosages. Multiple unit dosage forms (MUDF) are made of such combinations. Each dosage may be loaded with the active or excipients for reliable control of dissolution in the GI tract and quantitatively filled into an empty capsule shell. Such equipment that enables multiple dosages is offered by ACG and has been perfected for over years thanks to close association with pharmaceutical companies.

Dosing of single or multiple tablets in various dosage strengths (up to 108 tablets in a single capsule) on existing high-speed capsule-filling machines have given rise to multiple possibilities. These possibilities can be turned into combinations of different dosage forms such as softgel and pellets in capsules to provide pharmacists with unprecedented options.

Tablet filling mechanisms use simple stack counts in either magazine format or disc format for the dose – depending on the shape, size, and coating on the tablets. Today’s high-speed capsule fillers are also built with vision inspection systems to ensure count accuracy and non-fill detection, value added features that assure product compliance and quality. The final product can alternatively be passed through format free 100% checkweighers enabled with group load cell technology from European pioneers.

Visit ACG at INTERPHEX 2015, Booth # 2553.

How to Achieve Controlled Release & Accurate Dosing and Numerous Combinations in Capsules

 

 

 

How to Achieve Controlled Release & Accurate Dosing and Numerous Combinations in Capsules


INTERPHEX

Learn more about the single source for complete biopharmaceutical manufacturing solutions that gathers 12,000 industry professionals each year.

 

About INTERPHEX

Official blog of: INTERPHEX New York - www.interphex.com
This entry was posted in General and tagged , , , , , . Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s